I'm basically done most of the main game and just finished with Dogtown. I'm waiting on a call from Reed to debrief before that's entirely done. After that, it's off to Hanako and what I have to assume is a straight path to the end of the game. All other side quests and story quests are done.
It's been a long time coming and I'm kind of dreading it being over (or close to it, depending on my satisfaction with the ending I get), but I'm glad to have finally sat down and played it. It's become one of my favorite games.