Did this back in April, but I didn't have enough Karma to post it at the time. I couldn't sleep one night, so started a new playthrough of the game around midnight or just after and beat the game in one night and in less than 13 hours.
When looking at the trophies, I noticed that you had to play with multiple modifiers on in order to get some of the trophies. So I decided just to run a game with all the modifiers on so I wouldn't waste time especially with the Iron Man (permadeath) modifier.