First, some context. San Andreas has been broken and rebroken many times over the years across its multiple versions, and there's one specific "trick" that's upended the speedrunning landscape multiple times. It actually originated in GTA: Vice City, where a trick known as Script Stack Underflow (SSU) was found that chopped an any% run down to around eight minutes. Way back in 2019, San Andreas runners found something similar that they called "Arbitrary Jump in Script", or AJS, specifically in the Window Store remaster of the game. This overly-complex trick essentially let speedrunners jump straight to the end of the game by doing a long series of very specific things such as killing a drug dealer, parking a bike in a very specific place, answering the phone at very specific times, and diligently avoiding vending machines at all costs.
Well now, speedrunners have figured out how to do AJS in the original PC version of San Andreas. It is also completely different in how it's set up, and is somehow even wackier than any of the versions that have come before. u/Vitosi4ek on Reddit has a really nice breakdown of all the steps involved (though some runners have already found ways to smooth out certain bits of it). These include: winning $10,000 on horse betting, making a clone of yourself, doing stunt jumps on a superbike, betting in the casino with negative money, changing your clothes, doing a dance minigame, running two Mission at the exact same time, and a lot more. All of this will hopefully, if the game doesn't crash, send you to the start of End of the Line Part 3, and let you finish the game right there.