It's not aimed for the lowest of the lowest latency, real use case performance matters more to me.
Hypervisior is on which can reduce latency afik, but then again vanguard runs eitherway which will HVIC and VBS eitherway.

Got it stable, on TM5 on 6000/2200 @ 28/36/36/36

Any direct improvements that are worth mentioning, let me know and i'll try it out.
Tried lowering the tRFC already, but was unstable on 460.

VDDIO is reported wrong due to sensor being on motherboard, real VDDIO is set at 1.392 (bios 1.370 but for some reason this MSI board pushes VDDIO voltages a little?)

Did try lowering tWRWRSD/DD to 6 as well, but that ended up being unstable.

My next aim after this running stable for a few days will be trying 6200/2200 on hopefully 1:1

Special thanks to all other people coming to my original post and help me out with some suggestions ❤️